Modeling for Control of Mean Arterial Blood Pressure (map) during Anesthesia

MODELING FOR CONTROL OF MEAN ARTERIAL BLOOD PRESSURE (MAP) DURING ANESTHESIA C. W. Frei1 M. Derighetti1 and A. M. Zbinden2 1 Automatic Control Laboratory Swiss Federal Institute of Technology (ETH) 8092 Z urich 2 Institute of Anesthesiology and Intensive Care Research Department Inselspital 3010 Bern Abstract: In this paper we are studying models to be used for the design of automatic controllers for mean arterial blood pressure (MAP) during anesthesia. We demonstrate that for controller design a high order nonlinear model derived from physiological arguments leads to weakly observable and controllable linearized models that are best reduced to lower order. Order suggestions are given based on the linearization of a physiological compartment model.